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Niagen IV: Next-Gen NAD+ Therapy

Cellular energy, without the wait.

As we age, NAD+ levels naturally drop, affecting energy, recovery, and cellular repair. Niagen IV takes a smarter path to restoring them. The NAD+ molecule itself is too large to enter your cells easily, which is why traditional NAD+ drips take hours and often feel uncomfortable. NR (nicotinamide riboside) is a smaller precursor that is readily absorbed and converted into NAD+ inside your cells, offering a smoother, faster route to the same destination. Niagen IV replenishes what time takes away.

A brief health consultation is required for all new clients so a naturopathic physician can confirm Niagen IV is right for you.

A Holistique-branded Niagen IV bag, the NAD+ precursor infusion offered at the Holistique IV Lounge in Bellevue

What It Is

What Is Niagen IV?

NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every cell of your body, playing a central role in energy production, metabolism, and cellular repair. As we age, NAD+ levels naturally decline, a decline that can be accelerated by stress, poor sleep, and everyday wear on the body.

Traditional NAD+ IV therapy delivers the molecule directly, but NAD+ is large and doesn't cross cell membranes easily, which is why sessions can run up to four hours and occasionally come with discomfort like nausea or headache. Niagen IV takes a different approach: NR is a smaller precursor that's readily absorbed and converted into NAD+ inside your cells, offering a smoother, faster path to the same destination.

An essential coenzyme

NAD+ powers energy production, metabolism, and cellular repair in every cell, and its levels naturally decline with age.

A smarter precursor

NR is a smaller molecule your cells readily absorb and convert into NAD+, rather than delivering the large NAD+ molecule directly.

A smoother path

Because NR is absorbed efficiently, sessions are shorter and formulated to minimize the discomfort of traditional NAD+ infusions.

The Holistique Experience

Why Clients Choose Niagen IV

Fast

Most sessions run 30–60 minutes, a fraction of the time of standard NAD+ infusions.

Comfortable

Formulated to minimize the side effects associated with traditional NAD+ IV.

Backed by research

NR is one of the most studied NAD+ precursors, supported by human clinical trials on safety and NAD+ elevation.

Relaxing setting

Unwind in our lounge while your body does the work.

Who It's For

Is Niagen IV Right for You?

Clients looking to support energy levels, recovery, and overall cellular health as part of a broader wellness routine.

Cofactors & Add-Ons

Enhance Your Session

Niagen IV can be paired with additional nutrients that support the body's NAD+ pathway or complement it through related mechanisms. Here's what each one does:

  • Magnesium

    A required cofactor for the enzyme that converts NR into NAD+ inside the cell, the first key step in the pathway.

  • Zinc

    Structurally essential to sirtuins, the enzyme family that uses NAD+ to power DNA repair and cellular regulation.

  • Glutathione

    The body's master antioxidant. NAD+ metabolism helps regenerate glutathione, while glutathione helps clear the oxidative byproducts of cellular energy production, a natural feedback loop.

  • Myers' Cocktail Blend

    A classic mix of B vitamins, vitamin C, and minerals that supports general energy and immune function alongside your Niagen IV.

  • Phosphatidylcholine

    A key building block of cell membranes, often chosen by clients focused on liver health and cellular repair alongside their NAD+ support.

A note on the science: Magnesium and zinc have established, direct roles in the enzymes that create and use NAD+. Glutathione has a real, complementary biochemical relationship with NAD+ metabolism. Myers' Cocktail ingredients and phosphatidylcholine are valuable additions in their own right, but support general wellness and liver/membrane health rather than the NAD+ pathway itself. These pairings are offered based on individual goals and provider guidance, not as a single studied combination.

Before & After

Before & After Your Session

Before Your Session

  • Eat a light meal 1–2 hours beforehand, don't arrive on an empty stomach.
  • Hydrate well the day before and the morning of your session.
  • Wear a short-sleeve or loose-sleeve top for easy IV access.
  • Bring your ID and complete any required health intake forms.

After Your Session

  • Continue drinking water throughout the day to support absorption.
  • Avoid alcohol for the remainder of the day.
  • Mild bruising or tenderness at the IV site is normal and typically resolves within a few days.
  • Some clients feel immediately refreshed, while others notice effects building over the following 24–48 hours.
  • Resume normal activity right away, no downtime is required.

Good to Know

Niagen IV is administered under naturopathic physician guidance. It is not recommended for those who are pregnant or nursing, and clients with an active cancer diagnosis or chronic kidney disease should consult their provider before treatment. A brief health consultation is required for all new clients.

FAQ

Frequently Asked Questions

  • How often should I get Niagen IV?

    Frequency depends on your individual goals and health profile. Many clients start with a single session to assess response, then follow a maintenance schedule recommended by their provider.

  • Is Niagen IV safe?

    Nicotinamide riboside (NR), the active ingredient in Niagen, has been studied in multiple human clinical trials and shown to be well tolerated. As with any IV therapy, a health consultation is required to confirm it's appropriate for you.

  • How is this different from a traditional NAD+ IV?

    Niagen IV uses NR, a smaller NAD+ precursor that's absorbed more efficiently than NAD+ itself. This typically means a shorter infusion time and fewer side effects like nausea or headache.

  • Will I feel results immediately?

    Some clients report feeling clearer and more energized shortly after their session, while for others the effects build gradually over the following day or two as NAD+ levels rise.

  • Can I add other treatments to my Niagen IV?

    Yes. Many clients pair Niagen IV with magnesium, zinc, glutathione, a Myers' Cocktail blend, or phosphatidylcholine depending on their wellness goals. See the add-ons section above for details.

  • Who shouldn't get Niagen IV?

    Niagen IV is not recommended for those who are pregnant or nursing. Clients with an active cancer diagnosis or chronic kidney disease should consult their provider first.

Niagen IV is administered under naturopathic physician guidance following a health consultation. It is not appropriate for everyone; your provider will review your health history to determine whether it's right for you.

Ready to feel the difference?

Book your Niagen IV session, or reach our care team to find out whether next-gen NAD+ therapy fits your wellness goals.

Book Your Niagen IV Session or reach our care team, call or text (425) 451-0404

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