Therapeutic Plasma Exchange (TPE) in Bellevue

Your physician will design a personalized plan based on your condition and health goals. Most patients experience the greatest benefit from a series of TPE sessions, as results are cumulative over time. Some complete an initial round of treatments, while others continue with maintenance sessions every few months to sustain improvements.

Yes. TPE has been used safely in hospitals and specialty clinics for over 50 years. Most patients experience no complications. Mild effects like temporary lightheadedness due to brief drops in blood pressure, tingling or cold sensation, mild stomach upset, or fatigue can occur and typically resolve quickly. Each treatment is continuously monitored by a trained apheresis nurse to ensure comfort and safety.

Aside from a brief needle insertion for IV access, most patients describe TPE as painless and well-tolerated. A nurse will use a local numbing agent to reduce discomfort, which can be reapplied for additional relief throughout the procedure. The replacement solution is warmed using a blood warmer with adjustable temperature settings to help maintain a stable temperature during infusion. Comfort items such as blankets, pillows, eye masks, headphones, or entertainment options are available to help you relax during the 2–3 hour procedure.

Albumin is a naturally occurring protein in human plasma that helps maintain fluid balance and transport essential nutrients throughout the body. During TPE, it's used as a replacement solution to restore the plasma volume removed during treatment and help reestablish the body's natural equilibrium. The albumin used in TPE is human-derived, follows rigorous safety and screening standards, and has been widely used as the most common replacement fluid for therapeutic plasma exchanges for decades.

Hydrate well the day before your treatment, eat a light meal, and wear short sleeves or loose-fitting clothing for IV access. Avoid over-hydrating the morning of your session, as you'll be connected to an apheresis device for several hours. Your care team will provide detailed pre-treatment instructions.

On the day of your treatment, avoid strenuous activity and take it easy for the rest of the day. Most people can return to normal activities within 24 hours. Drink fluids, eat a balanced meal, and rest if you feel tired. Some providers recommend post-treatment lab work to track your progress, and your care team will guide you.

TPE is a self-pay service. However, Holistique can provide a superbill upon request for patients who wish to submit for potential reimbursement through their insurance plan.

Holistique delivers therapeutic plasma exchange in a modern, restorative environment, bringing a hospital-level procedure into a comfortable, outpatient setting. Every session is guided by medical expertise, advanced apheresis technology, and a standard of care designed for safety, comfort, and confidence.