Therapeutic Plasma Exchange (TPE)
in Bellevue
Therapeutic Plasma Exchange is an advanced, evidence-based procedure that filters your blood to remove inflammatory proteins, toxins, and environmental exposures. The result: a refreshed system primed for healthier aging.
Holistique is among a select few Washington centers offering TPE for symptom relief, chronic conditions, and longevity-focused care.
Technology
What is Therapeutic Plasma Exchange (TPE)?
Therapeutic Plasma Exchange is a well-established medical procedure that gently separates your blood to remove and replace the plasma, the liquid portion that carries proteins and other substances. This process helps clear components that may contribute to inflammation, immune dysfunction, or accelerated aging.
Therapeutic Plasma Exchange sessions generally last 2–4 hours. The procedure is well tolerated, and most patients recover quickly with minimal downtime.
PROCEDURE
How TPE Works
Blood is drawn through a small IV line and passed through an FDA-cleared device that separates plasma from your blood cells.
The plasma, which can contain inflammatory or disease-related substances, is removed.
Your plasma is replaced with a purified protein solution, typically albumin mixed with saline, to help restore healthy balance in circulation.
Your red and white blood cells and platelets are then safely returned to your body.
CONDITIONS & CONCERNS
Who May Benefit from Therapeutic Plasma Exchange
Therapeutic Plasma Exchange is used in a range of health contexts where circulating factors in the blood are believed to play a role in inflammation, immune stress, or stalled recovery. TPE has been used in clinical medicine for decades and is recognized by the American Society for Apheresis (ASFA) for conditions affecting the immune, blood, and metabolic systems. It is also being studied for its potential to support healthy aging and overall vitality.
The examples below reflect common situations where plasma exchange has been studied or considered, based on clinical experience and emerging research.
Autoimmune & Inflammatory Conditions
Long-COVID
Lyme Disease
Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
Chronic Pain
Mold Toxicity
Mercury Ingestion
Microplastics Burden
Neurological Concerns
Alzheimer's Disease
POTS (Postural Orthostatic Tachycardia Syndrome)
Paraneoplastic Neurological Syndrome
Cognitive Decline or Brain Fog
Recovery & Wellness
Chronic Fatigue Syndrome
Post-exertional Malaise (PEM)
Wellness Optimization & Longevity Promotion
LEARN MORE
Learn about microplastics and how plasma exchange may help.
PATIENT CANDIDATES
Candidates for TPE Therapy
Candidates for TPE are typically people where circulating factors in the blood may be contributing to inflammation, immune dysregulation, or difficulty recovering. This may include individuals with chronic illness, immune imbalance, or those seeking deeper physiologic restoration as part of a broader health strategy.
A complimentary consultation at Holistique is recommended to determine whether the procedure is safe and appropriate based on individual health factors.
Ready to Get Started?
Start with a consultation to explore what Therapeutic Plasma Exchange can do for you.
or reach our care team, call or text (425) 451-0404
FREQUENTLY ASKED QUESTIONS
Common Questions About TPE
How many treatments will I need?
Your physician will design a personalized plan based on your condition and health goals. Most patients experience the greatest benefit from a series of TPE sessions, as results are cumulative over time. Some complete an initial round of treatments, while others continue with maintenance sessions every few months to sustain improvements.
Is TPE safe?
Yes. TPE has been used safely in hospitals and specialty clinics for over 50 years. Most patients experience no complications. Mild effects like temporary lightheadedness due to mild drops in blood pressure, tingling sensations or cold sensation, mild stomach upset, or fatigue can occur and typically resolve quickly. Each treatment is continuously monitored by a trained apheresis nurse to ensure comfort and safety.
Will it hurt?
Aside from a brief needle insertion for IV access, most patients describe TPE as painless and well-tolerated. A Circulate nurse will use a local numbing agent to reduce discomfort, which can be reapplied for additional relief throughout the procedure. The replacement solution is warmed as it enters the body using a blood warmer, which has adjustable temperature settings to help maintain a stable temperature and to help prevent the chill some patients may experience during infusion. Some clinics also offer comfort items such as blankets, pillows, eye masks, headphones, or entertainment options to help patients relax during the 2–3 hour procedure. You're also welcome to bring your own light blanket if that makes you more comfortable.
What is albumin — and why is it used?
Albumin is a naturally occurring protein in human plasma that helps maintain fluid balance and transport essential nutrients throughout the body. During TPE, it's used as a replacement solution to restore the plasma volume removed during treatment and help reestablish the body's natural equilibrium. The albumin used in TPE is human-derived, following rigorous safety and screening standards and has been widely used as the most common type of replacement fluid for therapeutic plasma exchanges for decades.
How should I prepare?
Hydrate well the day before your treatment, eat a light meal, and wear short sleeves or loose fitting clothing for IV access. Avoid over-hydrating the morning of your session, as you'll be connected to an apheresis device for several hours. Your clinic team will provide detailed pre-treatment instructions.
What should I expect after treatment?
On the day of your treatment, you should avoid strenuous activity and take it easy for the rest of the day. Most people can return to normal activities within 24 hours. Drink fluids, eat a balanced meal, and rest if you feel tired. Some providers recommend post-treatment lab work to track your progress — your care team will guide you.
Does insurance cover TPE?
TPE is a self pay service. However, Holistique can provide a superbill upon request for patients who wish to submit for potential reimbursement through their insurance plan.
What makes Holistique's TPE experience different?
Holistique delivers therapeutic plasma exchange in a modern, restorative environment, bringing a hospital-level procedure into a comfortable, outpatient setting. Every session is guided by medical expertise, advanced apheresis technology, and a standard of care designed for safety, comfort, and confidence.
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